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As newer GLP-1 therapies produce substantial A1C reductions, clinicians are revisiting this phenomenon with renewed interest

Some notice increased energy as their blood sugars stabilize and they start to feel healthier

In a study of more than 3,000 adults with obesity, the highest dose of orforglipron resulted in an average weight loss of 27.3 pounds over 72 weeks, with a safety profile consistent with injectable GLP-1s

Future human studies will help us to better understand the big picture of this relationship, to hopefully provide mechanistic knowledge upon which new treatments could be created, such as microbiome-directed gene-therapies for the management of metabolic diseases

Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, et al